Formulasi dan Evaluasi Fisik Patch Mukoadhesif Ekstrak Biji Trembesi (Samanea saman (Jacq.) Merr.) Sebagai Kandidat Terapi Recurrent Aphthous Stomatitis

Authors

Suharti Suharti Program Studi D3 Farmasi, Sekolah Tinggi Ilmu Kesehatan Holistik, Purwakarta. Indonesia.
Taufik septiyan Universitas Al Ghifari
Siti Julianingsih Program Studi D3 Farmasi, Sekolah Tinggi Ilmu Kesehatan Holistik, Purwakarta. Indonesia.

DOI:

https://doi.org/10.61329/pscp.v4i2.72

Keywords:

Ekstrak Biji Trembesi, Formulasi, Patch Mukoadhesif, Evaluasi Fisik.

Abstract

Recurrent Aphthous Stomatitis (RAS) merupakan gangguan mukosa oral yang ditandai ulkus nyeri dan dapat mengganggu aktivitas sehari-hari. Penelitian ini bertujuan memformulasikan dan mengevaluasi sifat fisik patch mukoadhesif ekstrak biji trembesi (Samanea saman (Jacq.) Merr.) sebagai potensi kandidat sediaan untuk RAS. Penelitian eksperimental dilakukan menggunakan tiga formula (FI, FII, dan FIII) dengan variasi PVP, HPMC, dan etil selulosa. Ekstrak diperoleh melalui ekstraksi etanol 70%. Evaluasi meliputi organoleptik, pH permukaan, keseragaman bobot, ketebalan, dan swelling index. Ketiga formula menunjukkan karakteristik organoleptik dan pH permukaan yang baik. Rata-rata ketebalan FI, FII, dan FIII berturut-turut sebesar 0,113 ± 0,0095; 0,118 ± 0,0103; dan 0,111 ± 0,0099 mm. FIII menunjukkan kemampuan mengembang tertinggi dibandingkan formula lainnya. Berdasarkan hasil evaluasi, FIII merupakan formula paling optimal berdasarkan hasil evaluasi fisik. Penelitian lanjutan diperlukan untuk mengevaluasi daya lekat, pelepasan bahan aktif, stabilitas, dan efektivitas in vivo.

Downloads

Download data is not yet available.

References

[1] J. Sánchez-Bernal, C. Conejero, and R. Conejero, “Recurrent Aphthous Stomatitis,” Actas Dermosifiliogr., vol. 111, no. 6, pp. 471–480, 2020, doi: 10.1016/j.ad.2019.09.004.

[2] C. Vitamia et al., “Natural and Synthetic Drugs Approached for the Treatment of Recurrent Aphthous Stomatitis Over the Last Decade,” Drug Des. Devel. Ther., vol. 18, pp. 1297–1312, 2024, doi: 10.2147/DDDT.S449370.

[3] S. Jacob, A. B. Nair, S. H. S. Boddu, B. Gorain, N. Sreeharsha, and J. Shah, “An updated overview of the emerging role of patch and film-based buccal delivery systems,” Pharmaceutics, vol. 13, no. 8, 2021, doi: 10.3390/pharmaceutics13081206.

[4] A. Di Michele et al., “Bioadhesive patches based on carboxymethyl cellulose/polyvinylpyrrolidone/bentonite composites and Soluplus® for skin admninistration of poorly soluble molecules,” Appl. Clay Sci., vol. 216, no. July 2021, p. 106377, 2022, doi: 10.1016/j.clay.2021.106377.

[5] Saptawati, T., Dayanti, E., Rachma, F.A. & Ovikariani (2022). Phytochemical screening of ethanol extract of trembesi fruit seeds (Samanea saman). Science and Community Pharmacy Journal, 1(2). DOI: 10.63520/scpj.v1i2.325

[6] K. Sur et al., “Proximate Analysis and Elemental Profile of S. saman Flower,” ES Gen., pp. 1–8, 2024, doi: 10.30919/esg1265.

[7] R. Kumar, T. Islam, and M. Nurunnabi, Mucoadhesive carriers for oral drug delivery, vol. 351. 2022. doi: 10.1016/j.jconrel.2022.09.024.

[8 ] Hidayat, T.S. (2026). Evaluasi makroskopis aktivitas antisariawan ekstrak biji trembesi (Samanea saman (Jacq.) Merr.) terhadap proses penyembuhan ulkus mukosa oral pada tikus putih. Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi, 14(1).

[9] I. Soladeo Simajuntak et al., “JICN: Jurnal Intelek dan Cendikiawan Nusantara Review: Uji Standarisasi Simplisia Herba Meniran (Phyllanthus Niruri L.) Review: Standardization Test Of Herba Meniransimplisia (Phyllanthus Niruri L.),” JICN J. Intelek dan Cendikiawan Nusant., no. 4, pp. 4714–4728, 2025, [Online]. Available: https://jicnusantara.com/index.php/jicn

[10] N. Annisa and S. Z. Najib, “Skrining Fitokimia Dan Penetapan Kadar Total Fenol,” Indones. J. Pharm. Herb. Med., vol. 1, no. 2, pp. 96–104, 2022.

[11] P. Panca, B. Chandra, D. R. Laksmitawati, D. Rahmat, S. Tinggi, and I. Kesehatan, “Skrining Fitokimia Dan Penetapan Kadar Flavonoid Total …(Chandra dkk,” vol. 1, no. 2, pp. 96–104, 2022.

[12] Govindasamy, P., Kesavan, B.R. & Narasimha, J.K. 2013, ‘Formulation of unidirectional release buccal patches of carbamazepine and study of permeation through porcine buccal mucosa’, Asian Pacific Journal of Tropical Biomedicine, vol. 3, no. 12, pp. 995–1002. doi:10.1016/S2221-1691(13)60192-6 [23] S. Inayah et al., “No Title,” no. November, pp. 20–21, 2018.

[13] N. Gilhotra and R. M. Gilhotra, “Formulation and optimization of mucoadhesive buccal patches of losartan potassium by using response surface methodology,” pp. 1–13, 2015, doi: 10.4103/2277-9175.168606.

[14] S. B. Majee, S. Gupti, T. Mishra, and R. Bera, “Journal of Drug Delivery and Therapeutics In vitro , ex vivo and in vivo studies on anti-hypertensive-loaded transdermal and buccal patches,” vol. 15, no. 3, pp. 142–150, 2025.

[15] R. Sabra, D. Kirby, V. Chouk, K. Malgorzata, and A. R. Mohammed, “Buccal Absorption of Biopharmaceutics Classification System III Drugs: Formulation Approaches and Mechanistic Insights,” Pharmaceutics, vol. 16, no. 12, 2024, doi: 10.3390/pharmaceutics16121563.

[16] N. D. Ananda and F. Sains, “Formulasi dan Uji Sifat Fisik Acne Patch Ekstrak Etanol Kulit Luar Buah Cempedak ( Artocarpus integer ( Thunb ). Merr ) dengan Variasi Konsistensi Polimer HPMC dan PVP Formulation and Test of Physical Properties Acne Patches Ethanol Extract of Cempedak Fruit Outer Skin ( Artocarpus integer ( Thunb .) Merr ) With Variations of HPMC and PVP Polymer Concentrations Abstrak,” 2024.

[17] S. Kuala, A. Farmasi, and P. Aceh, “Pengaruh penggunaan polimer hpmc dan polivinil pirolidon terhadap karakteristik fisik transdermal patch natrium diklofenak,” vol. 1, no. November 2020, pp. 58–66, 2021.

[18] E. P. Hartianty, A. Kurnia, and S. Mardiyanti, “Formulasi dan Evaluasi Sediaan Granul Mukoadhesif Amoksisilin Trihidrat dengan Polimer Kitosan Artikel Penelitian,” vol. 15, pp. 188–194, 2023.